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Prolonged QTc Interval, CTCAE

MedGen UID:
409584
•Concept ID:
C1963217
•
Finding

Definition

An adverse event characterized by an abnormally long interval between the start of the Q wave and the end of the T wave in the heart''s electrical cycle, corrected for heart rate. [from NCI]

Professional guidelines

PubMed

Association of QTc Formula With the Clinical Management of Patients With Cancer.
Richardson DR, Parish PC, Tan X, Fabricio J, Andreini CL, Hicks CH, Jensen BC, Muluneh B, Zeidner JF
JAMA Oncol 2022 Nov 1;8(11):1616-1623. doi: 10.1001/jamaoncol.2022.4194. PMID: 36136321Free PMC Article

Recent clinical studies

Etiology

Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients.
Sabatino DC, Lange NW, Salerno DM, Scheffert J
Clin Transplant 2023 Jan;37(1):e14826. Epub 2022 Oct 26 doi: 10.1111/ctr.14826. PMID: 36205935
Association of QTc Formula With the Clinical Management of Patients With Cancer.
Richardson DR, Parish PC, Tan X, Fabricio J, Andreini CL, Hicks CH, Jensen BC, Muluneh B, Zeidner JF
JAMA Oncol 2022 Nov 1;8(11):1616-1623. doi: 10.1001/jamaoncol.2022.4194. PMID: 36136321Free PMC Article
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.
Kloth JS, Pagani A, Verboom MC, Malovini A, Napolitano C, Kruit WH, Sleijfer S, Steeghs N, Zambelli A, Mathijssen RH
Br J Cancer 2015 Mar 17;112(6):1011-6. doi: 10.1038/bjc.2015.82. PMID: 25742483Free PMC Article

Diagnosis

Association of QTc Formula With the Clinical Management of Patients With Cancer.
Richardson DR, Parish PC, Tan X, Fabricio J, Andreini CL, Hicks CH, Jensen BC, Muluneh B, Zeidner JF
JAMA Oncol 2022 Nov 1;8(11):1616-1623. doi: 10.1001/jamaoncol.2022.4194. PMID: 36136321Free PMC Article

Therapy

Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients.
Sabatino DC, Lange NW, Salerno DM, Scheffert J
Clin Transplant 2023 Jan;37(1):e14826. Epub 2022 Oct 26 doi: 10.1111/ctr.14826. PMID: 36205935
Safety and antitumor activity of arsenic trioxide plus infusional 5-fluorouracil, leucovorin, and irinotecan as second-line chemotherapy for refractory metastatic colorectal cancer: A pilot study from South India.
Lakshmaiah KC, Chaudhuri T, Babu GK, Lokanatha D, Jacob LA, Suresh Babu MC, Rudresha AH, Lokesh KN, Rajeev LK
Indian J Cancer 2017 Oct-Dec;54(4):631-633. doi: 10.4103/ijc.IJC_374_17. PMID: 30082548
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.
Kloth JS, Pagani A, Verboom MC, Malovini A, Napolitano C, Kruit WH, Sleijfer S, Steeghs N, Zambelli A, Mathijssen RH
Br J Cancer 2015 Mar 17;112(6):1011-6. doi: 10.1038/bjc.2015.82. PMID: 25742483Free PMC Article

Prognosis

Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.
Kloth JS, Pagani A, Verboom MC, Malovini A, Napolitano C, Kruit WH, Sleijfer S, Steeghs N, Zambelli A, Mathijssen RH
Br J Cancer 2015 Mar 17;112(6):1011-6. doi: 10.1038/bjc.2015.82. PMID: 25742483Free PMC Article

Clinical prediction guides

Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients.
Sabatino DC, Lange NW, Salerno DM, Scheffert J
Clin Transplant 2023 Jan;37(1):e14826. Epub 2022 Oct 26 doi: 10.1111/ctr.14826. PMID: 36205935
Association of QTc Formula With the Clinical Management of Patients With Cancer.
Richardson DR, Parish PC, Tan X, Fabricio J, Andreini CL, Hicks CH, Jensen BC, Muluneh B, Zeidner JF
JAMA Oncol 2022 Nov 1;8(11):1616-1623. doi: 10.1001/jamaoncol.2022.4194. PMID: 36136321Free PMC Article
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.
Kloth JS, Pagani A, Verboom MC, Malovini A, Napolitano C, Kruit WH, Sleijfer S, Steeghs N, Zambelli A, Mathijssen RH
Br J Cancer 2015 Mar 17;112(6):1011-6. doi: 10.1038/bjc.2015.82. PMID: 25742483Free PMC Article

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